Saccharomyces has a certain enrichment ability for metal elements. It can convert inorganic zinc to organic form and can be used as a zinc carrier. Zinc that is bound to different macromolecules in yeast cells has been proven to have a better absorbability in the human body. In this study, a large number of strains (96 strains) belonging to the genus Saccharomyces were screened, and their ability of zinc accumulation was determined. The cultivations were performed on the Sabouraud dextrose broth medium with the addition of zinc nitrate at the concentration of 1000 mg/l, incubated at 28oC on a rotary shaker (150 rpm) for 72 hours. The results showed that there was a linear correlation between the zinc nitrate supplementation in the culture medium and the amount of zinc accumulated in the biomass. The highest organic zinc accumulation of 8916 mg/kg was observed in the strain S. cerevisiae 2049. It would be a promising candidate for production of zinc enriched yeasts at the industrial scale in Vietnam.