Foraminifera and calcareous nannofossil are widely used in the marine biostratigraphy study due to their rapid evolution and wide distribution. Through many years of studying Pliocene-Quaternary in the east of the Vietnam continental shelf via oil and gas exploration wells, the authors found that these two fossil groups were really effective tools for dividing details these sediments. The A, B, C, D, E, and F wells were chosen as a presentative for the study area. Following the standard zonal schemes of planktonic foraminifera “N” Blow and “PL” & “PT” Wade et al.; the standard zonal schemes of calcareous nannofossil “NN” Martini and “CNPL” Backman et al., the Pliocene-Quaternary biostratigraphic framework in the studied area were established. In this study, the early Pliocene sediments were limited to the foraminifera zone PL1-PL3/upper N18-N19, corresponding to the nannofossil zone CNPL1-CNPL3/NN12-NN15. The late Pliocene sediments consisted of the foraminifera zone PL4-PL6/N20-N21, corresponding to the nannofossil zone CNPL4-CNPL6/NN16-NN18. The early Pleistocene sediments were characterised by foraminifera subzone PT1a/the lower N22, approximate to the nannofossil zone CNPL7-CNPL10/NN19. The late Pleistocene sediments include the foraminifera subzone PT1b/the upper N22 and nannofossil zone CNPL11/NN20-NN21. The results exhibited that the suitability of stratigraphic division in the studied area with the standard zonal schemes in the Pliocene-Quaternary period in Pacific and low-latitude oceans. This is a premise to apply for the stratigraphic study and correlation in the Vietnam continental shelf and adjacent areas.